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LCP (Lipidic cubic phase) sandwich set

(27.01.2010)

The LCP Sandwich consists of a base glass slide and an optimized cover slip.

LCP Sandwich Set

LCP sandwich set

This product has been developed jointly with the renowned Scripps Research Institute in La Jolla, California, USA.

Bottom slide:

  • dimensions: approx 127.8x85.5x1 mm
  • with superhydrophobic glass surface
  • covered with a 0.2 mm high spacer. This spacer has 96 recesses of 5mm diameter. They are consistent with the SBS format for robotic handling. The spacer has an adhesive surface to which the hydrophobic coverslip attaches. The crystallization drops are, hence, sealed in these reaction chambers.

Cover slip:

  • optimized for bright field, UV and fluorescent microscopy
  • dimensions: approx 112x77 mm, thickness No. 1.5 (0.16 - 0.19 mm)
  • with superhydrophobic glass surface

Application:

  • optimized for the crystallographic study of membrane proteins. References: V. Cherezov, J. Clogston, M. Z. Papiz, M. Caffrey (2006) Room to Move: Crystallizing Membrane Proteins in Swollen Lipidic Mesophases. Journal of Molecular Biology 357, 1605 – 1618
  • developed at the NIH Roadmap Center for membrane protein research (http://jcimpt.scripps.edu) and routinely used in GPCR structural biology. References: V. Cherezov, D. M. Rosenbaum, M. A. Hanson, S. G. Rasmussen, F. S. Thian, T. S. Kobilka, H. J. Choi, P. Kuhn, W. I. Weis, B. K. Kobilka and R. C. Stevens (2007) High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science 318: 1258-65
  • other applications using LCP membrane protein structure based in drug design

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